Sally Temple, Ph.D.

Professor and Scientific Director
Adjunct Professor, University at Albany
New York Neural Stem Cell Institute
sallytemple@nynsci.org

Dr. Temple is studying how embryonic neural progenitor cells generate the numerous, diverse, cell types of the adult CNS. These studies may lead to therapies for neurodegenerative disorders or for neural tumors. The Temple laboratory has designed a culture system in which single CNS progenitor cells can divide and differentiate into clones of neurons and glial cells. This led to the identification of different classes of progenitor cells in embryonic forebrain, including one that may play a key role in brain development. Molecular mechanisms regulating division and differentiation of brain progenitor cells will be the focus of future studies in the Temple lab.

Select Publications

Lowry, N., Goderie, S.K., Adamo, M., Lederman, P., Charniga, C., Gill, J., Silver, J., Temple, S. (2008). Multipotent embryonic spinal cord stem cells expanded by endothelial factors and SHH/RA promote functional recovery after SCI.  Exp Neurol. 209(2) 510-22. 

Kokovay, E., Temple, S. (2007).  Taking neural crest stem cells to new heights.  Cell 131, 284-236.

Fasano, C.A., Dimos, J.T., Ivanova, N.B., Lowry, N., Lemischka, I.R., and Temple, S. (2007) shRNA knowckdown of Bmi-1 reveals a critical role for p21/Rb pathway in NSC self-renewal during development.  Cell Stem Cell 1, 87-99.